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Directions. Take Neoral exactly as prescribed by your doctor. For solid organ transplants, the recommended dose is 10 mg to 15 mg per kilogram of body weight daily (in 2 divided doses) starting at least 12 hours before surgery. For bone marrow transplants, the medication is usually given at a daily dose of about 12.5 mg per kilogram of body weight in 2 divided doses. For treatment of psoriasis, the recommended starting dose is 2 mg per kilogram of body weight per day in 2 divided doses. For treatment of rheumatoid arthritis, the recommended dose is 2 mg per kilogram of body weight per day in 2 divided doses for the first 6 weeks of treatment. For nephrotic syndrome, the recommended starting dose is 3.5 mg per kilogram of body weight per day for adults and 4.2 mg per kilogram of body weight per day for children. People with reduced kidney function should not receive more than 2.5 mg per kg body weight per day. You may take this medication with or without food. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication.
General information. Neoral belongs to a class of drugs known as immunosuppressants. Neoral contains a modified form of cyclosporine. It works by slowing down your body's defense system (immune system) to prevent your body from rejecting a transplanted organ, further damaging your joints (in rheumatoid arthritis patients), or further damaging your skin (in psoriasis patients). This medication is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Neoral is also used to treat severe rheumatoid arthritis and a certain skin condition (severe psoriasis). This drug may also be used to prevent rejection in other types of organ transplants (e.g., cornea, pancreas) or bone marrow transplant. It may also be used to treat other conditions that may be helped by affecting the immune system (e.g., Crohn's disease).


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Drug interactions. Tell your doctor about all other medications you use, especially: aliskiren, allopurinol, blood pressure medicines, ACE inhibitors (benazepril, lisinopril, ramipril, enalapril), lithium, calcium channel blockers, colchicine, cancer medicine (ifosfamide, carmustine, tretinoin), dabigatran, digoxin, echinacea, fentanyl, methotrexate, pain or arthritis medicines (aspirin, ibuprofen, naproxen, acetaminophen), methylprednisolone, antiviral medicines (cidofovir, adefovir, foscarnet), natalizumab, nonsteroidal anti-inflammatory drugs (celecoxib, etodolac, diclofenac, ibuprofen, indomethacin), orlistat, pimecrolimus, potassium-sparing diuretics (spironolactone, amiloride, triamterene), statin medications (pitavastatin, simvastatin, fluvastatin), tacrolimus, tolvaptan, topotecan. Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking.
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